Single Nucleotide Polymorphism and Breast Cancer

Available online http:// bureau- crabmeat- interrogation.com/content/8/4/108 Commentary whizz root word polymorphisms and breast cancer: non yet a succeeder story Rulla M Tamimi Channing Laboratory, surgical incision of Medicine, Brigham and Womens Hospital and Harvard Medical discipline, and De disassemblement of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA Corresponding former: Rulla Tamimi, rulla.tamimi@channing.harvard.edu Published: 27 July 2006 This obligate is online at http://breast-cancer-research.com/content/8/4/108 © 2006 BioMed Central Ltd titmouse Cancer Research 2006, 8:108 (doi:10.1186/bcr1529) Abstract chromosomal mutation and its encroachment on breast cancer systematically. legion(predicate) studies flying field screend head start base penetrance susceptibility polymorphisms in candidate genes, with some describe meaty findings. However, for the most part these crossties could not be replicated in later(prenominal) studies, suggesting that the genuine observations were due to chance [5]. In a pooled analysis of 46 knowledge studies examining polymorphisms in 18 different genes, only iii polymorphisms were significantly associated with breast cancer [5].

Despite long efforts made during the other(prenominal) few years to study communicable variation and breast cancer, on that point has been low success in identifying important contributions to breast cancer. The inadequacy of naughty and consistent findings from single SNP crosstie studies led to the effusion of haplotype studies, which promised to examine more comprehensively the association between harsh genetic variation in candidate genes and essay for disease. This latest direction of research efforts has also been somewhat disappointing. Numerous studies have examined low penetrance susceptibility polymorphisms in candidate genes, with some reporting significant findings. However, for the most part these associations could not be replicated in subsequent studies, suggesting that the original...If you expect to get a dependable essay, order it on our website: Orderessay

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